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University
Shawnee State University
Presentation Types
Oral Group Presentation
Keywords:
cancer, matcha
Abstract
Acute Myeloid Leukemia (AML) is a devastating blood cancer with a very low survival rate. Green tea and matcha green tea (MGT) have recently been an area of interest in research due to their antioxidant components, such as the polyphenol epigallocatechin-3-gallate. These polyphenols are more concentrated in MGT than in other types of green tea due to the preparation of the tea. In our research, we have observed a dosage-dependent decrease of viable AML cells with MGT treatment. Our next steps will involve employing western blotting to assay the expression of various target proteins involved in cell cycle progression and apoptosis to try and determine possible mechanisms of cell toxicity.
Human Subjects
no
Faculty Mentor Name
Jennifer Napper
Faculty Mentor Title
Associate Professor of Biology
Faculty Mentor Academic Department
Natural Sciences
Recommended Citation
Long, Megan and Bruening, Alena, "The Effects of Matcha Green Tea on HL-60 and THP-1 Acute Myeloid Leukemia Cells" (2021). Celebration of Scholarship. 2.
https://digitalcommons.shawnee.edu/cos/2021/day3/2
The Effects of Matcha Green Tea on HL-60 and THP-1 Acute Myeloid Leukemia Cells
Acute Myeloid Leukemia (AML) is a devastating blood cancer with a very low survival rate. Green tea and matcha green tea (MGT) have recently been an area of interest in research due to their antioxidant components, such as the polyphenol epigallocatechin-3-gallate. These polyphenols are more concentrated in MGT than in other types of green tea due to the preparation of the tea. In our research, we have observed a dosage-dependent decrease of viable AML cells with MGT treatment. Our next steps will involve employing western blotting to assay the expression of various target proteins involved in cell cycle progression and apoptosis to try and determine possible mechanisms of cell toxicity.