University
Shawnee State University
Major
Biology - Biomedical Sciences
Presentation Types
Oral Presentation (Live)
Abstract
Diphenhydramine is an over-the-counter antihistamine drug used for allergic reactions taken by millions of individuals each year. The safety of taking this medicine relative to embryonic and fetal development is unknown. Chick embryos will be used to assess teratogenic effects of diphenhydramine. This model may also give insight into whether the drug can cross the placental barrier. A comparable dose of diphenhydramine seen in a mother’s bloodstream will be injected into yolks at specific stages of chick development to examine potential defects.
Chick development is similar to that of mammals, and the egg allows a relatively constant internal environment enabling effects of the teratogen to be clearly distinguished. Using the Hamburger Hamilton staging system, a developmental score will be assigned to embryos based on their anatomical development. Various stages will be tested to determine if there are time-dependent effects of medication on developmental outcomes compared to controls.
Human and Animal Subjects
no
IRB or IACUC Approval
no
Faculty Mentor Name
Kimberly Inman
Faculty Mentor Title
Associate Professor of Biology
Faculty Mentor Department
Natural Sciences
Recommended Citation
Arey, Tanner, "Teratogenic effect of diphenhydramine on chick embryonic development." (2021). Celebration of Scholarship. 1.
https://digitalcommons.shawnee.edu/cos/2021/day5/1
Teratogenic effect of diphenhydramine on chick embryonic development.
Diphenhydramine is an over-the-counter antihistamine drug used for allergic reactions taken by millions of individuals each year. The safety of taking this medicine relative to embryonic and fetal development is unknown. Chick embryos will be used to assess teratogenic effects of diphenhydramine. This model may also give insight into whether the drug can cross the placental barrier. A comparable dose of diphenhydramine seen in a mother’s bloodstream will be injected into yolks at specific stages of chick development to examine potential defects.
Chick development is similar to that of mammals, and the egg allows a relatively constant internal environment enabling effects of the teratogen to be clearly distinguished. Using the Hamburger Hamilton staging system, a developmental score will be assigned to embryos based on their anatomical development. Various stages will be tested to determine if there are time-dependent effects of medication on developmental outcomes compared to controls.
