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University

Shawnee State University

Major

Biomedical Sciences

Student Type

Undergraduate Student

Presentation Types

Oral Group Presentation

Keywords:

Myxoccocus xanthus, E. coli, Caco-2, bacterial infection

Abstract

The interaction between bacteria and host cells can have significant effects on the health and well-being of organisms. The predatory nature of Myxococcus xanthus suggests that its presence may have a mitigating effect on the attachment of E. coli in tissue culture. In this study, we investigated the effect of M. xanthus on E. coli infected human intestinal epithelial cells (Caco-2 cells). Using in vitro assays, we observed the growth and characteristics of Caco-2 cells after exposure to both bacteria. However, further experimentation is necessary to confirm and better understand the underlying mechanisms at play. These results have important implications for our understanding of how bacterial communities interact with host cells, and how these interactions can influence health outcomes. In particular, M. xanthus may have a beneficial effect on the gut microbiome, potentially providing a new avenue for the development of probiotics or other microbiome-based antimicrobial therapies. Overall, this study contributes to a growing body of research on the complex interactions between bacteria and host cells which highlights the need for further investigation.

Human Subjects

no

IRB Approval

no

Faculty Mentor Name

Eugene Burns

Faculty Mentor Title

Dr.

Faculty Mentor Academic Department

Natural Sciences

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Fighting Fire with Fire: The Effects of Myxococcus xanthus on E. coli infected Caco-2 Cells

The interaction between bacteria and host cells can have significant effects on the health and well-being of organisms. The predatory nature of Myxococcus xanthus suggests that its presence may have a mitigating effect on the attachment of E. coli in tissue culture. In this study, we investigated the effect of M. xanthus on E. coli infected human intestinal epithelial cells (Caco-2 cells). Using in vitro assays, we observed the growth and characteristics of Caco-2 cells after exposure to both bacteria. However, further experimentation is necessary to confirm and better understand the underlying mechanisms at play. These results have important implications for our understanding of how bacterial communities interact with host cells, and how these interactions can influence health outcomes. In particular, M. xanthus may have a beneficial effect on the gut microbiome, potentially providing a new avenue for the development of probiotics or other microbiome-based antimicrobial therapies. Overall, this study contributes to a growing body of research on the complex interactions between bacteria and host cells which highlights the need for further investigation.