Recorded Presentations
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University
Shawnee State University
Major
Biomedical Sciences
Presentation Types
Oral Group Presentation
Keywords:
Myxoccocus xanthus, E. coli, Caco-2, bacterial infection
Abstract
The interaction between bacteria and host cells can have significant effects on the health and well-being of organisms. The predatory nature of Myxococcus xanthus suggests that its presence may have a mitigating effect on the attachment of E. coli in tissue culture. In this study, we investigated the effect of M. xanthus on E. coli infected human intestinal epithelial cells (Caco-2 cells). Using in vitro assays, we observed the growth and characteristics of Caco-2 cells after exposure to both bacteria. However, further experimentation is necessary to confirm and better understand the underlying mechanisms at play. These results have important implications for our understanding of how bacterial communities interact with host cells, and how these interactions can influence health outcomes. In particular, M. xanthus may have a beneficial effect on the gut microbiome, potentially providing a new avenue for the development of probiotics or other microbiome-based antimicrobial therapies. Overall, this study contributes to a growing body of research on the complex interactions between bacteria and host cells which highlights the need for further investigation.
Human Subjects
no
IRB Approval
no
Faculty Mentor Name
Eugene Burns
Faculty Mentor Title
Dr.
Faculty Mentor Academic Department
Natural Sciences
Recommended Citation
Luthy, Laura; Bauer, Kolton; and Thacker, Hannah, "Fighting Fire with Fire: The Effects of Myxococcus xanthus on E. coli infected Caco-2 Cells" (2023). Celebration of Scholarship. 1.
https://digitalcommons.shawnee.edu/cos/2023/Day3/1
Fighting Fire with Fire: The Effects of Myxococcus xanthus on E. coli infected Caco-2 Cells
The interaction between bacteria and host cells can have significant effects on the health and well-being of organisms. The predatory nature of Myxococcus xanthus suggests that its presence may have a mitigating effect on the attachment of E. coli in tissue culture. In this study, we investigated the effect of M. xanthus on E. coli infected human intestinal epithelial cells (Caco-2 cells). Using in vitro assays, we observed the growth and characteristics of Caco-2 cells after exposure to both bacteria. However, further experimentation is necessary to confirm and better understand the underlying mechanisms at play. These results have important implications for our understanding of how bacterial communities interact with host cells, and how these interactions can influence health outcomes. In particular, M. xanthus may have a beneficial effect on the gut microbiome, potentially providing a new avenue for the development of probiotics or other microbiome-based antimicrobial therapies. Overall, this study contributes to a growing body of research on the complex interactions between bacteria and host cells which highlights the need for further investigation.