The Effects of Honokiol on HL-60 Acute Myeloid Leukemia

Gavin MeadowsFollow

University

Shawnee State University

Major

Biology-Biological Sciences

Student Type

Undergraduate Student

Presentation Types

Oral Presentation

Keywords:

honokiol, cancer, acute myeloid leukemia, HSP90

Abstract

Acute myeloid leukemia is a bone marrow and blood cancer affecting the body’s myeloblasts, red blood cells, and platelets, leading to anemia and weakness. High levels of HSP90 have been observed in leukemia during rapid cell proliferation. Research has shown that leukemia and other cancerous cells can be destroyed using the compound honokiol. Honokiol is a naturally occurring phenolic compound found in the bark of the Asian Magnolia tree and is commonly used as a dietary supplement. It has also been shown to downregulate HSP90. The aim of this study is to investigate the toxicity of honokiol in acute myeloid leukemia in conjunction with HSP90. When HL-60 acute myeloid leukemia cells are treated with varying doses of honokiol, significant cell death is observed in any dosage above 20 μM.

Human Subjects

no

IRB Approval

no

Faculty Mentor Name

Dr. Jennifer Napper

Faculty Mentor Title

Associate Professor of Biology

Faculty Mentor Academic Department

Natural Sciences

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The Effects of Honokiol on HL-60 Acute Myeloid Leukemia

Acute myeloid leukemia is a bone marrow and blood cancer affecting the body’s myeloblasts, red blood cells, and platelets, leading to anemia and weakness. High levels of HSP90 have been observed in leukemia during rapid cell proliferation. Research has shown that leukemia and other cancerous cells can be destroyed using the compound honokiol. Honokiol is a naturally occurring phenolic compound found in the bark of the Asian Magnolia tree and is commonly used as a dietary supplement. It has also been shown to downregulate HSP90. The aim of this study is to investigate the toxicity of honokiol in acute myeloid leukemia in conjunction with HSP90. When HL-60 acute myeloid leukemia cells are treated with varying doses of honokiol, significant cell death is observed in any dosage above 20 μM.