Response of Feeder Calves to Pasteurella multocida Vaccine

Michelle NoelFollow

University

Shawnee State University

Major

Biomedical Sciences

Student Type

Undergraduate Student

Presentation Types

Poster Presentation

Keywords:

antibodies, pasteurella, calves, vaccine

Abstract

The leading problem faced by the beef cattle industry, primarily by the feedlot sector, is the common occurrence of bovine respiratory disease (BRD), which can be caused by a variety of different bacterial infections. It is chiefly attributed to Mannheimia haemolytica. The second most common pathogen cultured from infected calves is Pasteurella multocida, an organism that is much less commonly studied but which is increasing in frequency in diseased calves. This research sought to investigate the ability of beef feeder calves to produce antibodies against this pathogen before and after being vaccinated using modified live vaccine. Antibody titers before and after vaccination were determined using ELISA. The results showed that vaccination did not have the impact expected. Post-vaccination antibody titers were not significantly higher than than pre-vaccination antibody titers. These results could be due to a genetic factor in these particular calves affecting their ability to produce antibodies in response to the vaccine. Considering the close genetic relation of the calves sampled, it makes sense that these results would be similar across all calf samples, as was observed. Alternatively, these results could indicate that the period between samplings (three weeks) was not sufficient for the vaccine to fully take effect. Further research would be required to determine this with any certainty.

Human Subjects

no

Faculty Mentor Name

Eugene Burns

Faculty Mentor Title

Dr.

Faculty Mentor Academic Department

Natural Sciences

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Response of Feeder Calves to Pasteurella multocida Vaccine

The leading problem faced by the beef cattle industry, primarily by the feedlot sector, is the common occurrence of bovine respiratory disease (BRD), which can be caused by a variety of different bacterial infections. It is chiefly attributed to Mannheimia haemolytica. The second most common pathogen cultured from infected calves is Pasteurella multocida, an organism that is much less commonly studied but which is increasing in frequency in diseased calves. This research sought to investigate the ability of beef feeder calves to produce antibodies against this pathogen before and after being vaccinated using modified live vaccine. Antibody titers before and after vaccination were determined using ELISA. The results showed that vaccination did not have the impact expected. Post-vaccination antibody titers were not significantly higher than than pre-vaccination antibody titers. These results could be due to a genetic factor in these particular calves affecting their ability to produce antibodies in response to the vaccine. Considering the close genetic relation of the calves sampled, it makes sense that these results would be similar across all calf samples, as was observed. Alternatively, these results could indicate that the period between samplings (three weeks) was not sufficient for the vaccine to fully take effect. Further research would be required to determine this with any certainty.